[14] Peñarol 0-1 Defensor Sporting [15] 2022-02-13 23:00
Estádio: Estádio Campeão do Siglo Round: 2
Juiz: Andres Matonte Home Manager: Jose Mauricio Larriera Away Manager: Eduardo Acevedo
Head to Head
| Uruguai - Clausura | 2021/01/28 00:00 | Peñarol v Defensor Sporting | L | 1-2 |
| Uruguai - Torneo Intermedio | 2020/11/01 21:00 | Defensor Sporting v Peñarol | L | 2-1 |
| Uruguai - Apertura | 2020/02/23 22:30 | Defensor Sporting v Peñarol | L | 2-1 |
| Uruguai - Clausura | 2019/09/14 22:00 | Peñarol v Defensor Sporting | W | 1-0 |
| Uruguai - Torneo Intermedio | 2019/08/11 21:00 | Defensor Sporting v Peñarol | D | 2-2 |
| Uruguai - Apertura | 2019/02/17 22:30 | Defensor Sporting v Peñarol | W | 0-1 |
| Uruguai - Clausura | 2018/11/04 19:30 | Defensor Sporting v Peñarol | W | 1-2 |
| Uruguai - Torneo Intermedio | 2018/06/07 18:00 | Defensor Sporting v Peñarol | W | 1-3 |
Home History
| Uruguai - Apertura | 2022/02/05 20:00 | Atletico Fenix Montevideo v Peñarol | L | 1-0 |
| Uruguai - Supercopa | 2022/01/30 22:00 | Plaza Colonia v Peñarol | W | 0-1 |
| Europa - Amigáveis | 2022/01/26 22:00 | Peñarol v Nacional de Football | W | 1-0 |
| América - Amigáveis | 2022/01/25 00:30 | Peñarol v Santiago Wanderers | W | 2-0 |
| América - Amigáveis | 2022/01/20 00:30 | Peñarol v Ñublense | W | 1-0 |
| Europa - Amigáveis | 2022/01/17 22:15 | Peñarol v Barracas Central | W | 4-0 |
| Uruguai - Clausura | 2021/12/07 23:30 | Plaza Colonia v Peñarol | W | 8-9 |
| Uruguai - Clausura | 2021/12/04 20:00 | Peñarol v IA Sud America | W | 3-1 |
Away History
| Uruguai - Apertura | 2022/02/05 22:30 | Defensor Sporting v Liverpool Montevideo | L | 0-3 |
| Europa - Amigáveis | 2022/01/29 22:15 | Defensor Sporting v Estudiantes | L | 1-4 |
| América - Amigáveis | 2022/01/19 00:30 | Defensor Sporting v Unión Española | L | 0-2 |
| América - Amigáveis | 2022/01/17 00:30 | Defensor Sporting v Danubio | L | 0-2 |
| Uruguay - Segunda | 2021/12/09 23:30 | Racing Club de Montevideo v Defensor Sporting | D | 0-0 |
| Uruguay - Segunda | 2021/12/07 00:45 | Defensor Sporting v Racing Club de Montevideo | W | 3-0 |
| Uruguay - Segunda | 2021/12/04 00:45 | Defensor Sporting v Cerro | L | 0-1 |
| Uruguay - Segunda | 2021/11/30 22:00 | Cerro v Defensor Sporting | W | 1-2 |