[1] Peñarol 3-1 IA Sud America [15] 2021-12-04 20:00
Estádio: Estádio Campeão do Siglo Round: 15
Juiz: Gustavo Tejera Home Manager: Jose Mauricio Larriera Away Manager: Luis Lopez
Head to Head
| Uruguai - Apertura | 2021/08/22 18:00 | IA Sud America v Peñarol | D | 1-1 |
| Uruguai - Clausura | 2017/11/08 23:00 | IA Sud America v Peñarol | W | 2-3 |
| Uruguai - Apertura | 2017/04/01 20:00 | Peñarol v IA Sud America | W | 4-0 |
| Uruguai - Apertura | 2016/10/29 19:00 | IA Sud America v Peñarol | W | 1-4 |
| Uruguai - Clausura | 2016/03/05 23:00 | Peñarol v IA Sud America | D | 1-1 |
| Uruguai - Apertura | 2015/09/13 21:30 | IA Sud America v Peñarol | W | 1-4 |
| Uruguai - Clausura | 2015/03/21 19:00 | IA Sud America v Peñarol | L | 1-0 |
| Uruguai - Apertura | 2014/09/12 22:00 | Peñarol v IA Sud America | D | 1-1 |
Home History
| Uruguai - Clausura | 2021/11/25 19:30 | Club Atlético Progreso v Peñarol | D | 0-0 |
| Uruguai - Clausura | 2021/11/23 00:45 | Peñarol v Cerro Largo FC | D | 2-2 |
| Uruguai - Clausura | 2021/11/14 19:30 | CA River Plate v Peñarol | D | 1-1 |
| Uruguai - Clausura | 2021/11/07 22:00 | Peñarol v Liverpool Montevideo | W | 1-0 |
| Uruguai - Clausura | 2021/11/05 00:30 | Cerrito v Peñarol | W | 1-3 |
| Uruguai - Clausura | 2021/10/31 19:00 | Peñarol v Nacional de Football | D | 0-0 |
| Uruguai - Clausura | 2021/10/23 22:00 | Villa Espanola v Peñarol | W | 1-3 |
| Uruguai - Clausura | 2021/10/20 23:30 | Peñarol v Torque | W | 3-1 |
Away History
| Uruguai - Clausura | 2021/11/26 12:45 | IA Sud America v Rentistas | W | 3-1 |
| Uruguai - Clausura | 2021/11/19 21:45 | Montevideo Wanderers v IA Sud America | L | 4-1 |
| Uruguai - Clausura | 2021/11/14 12:45 | IA Sud America v Boston River | L | 1-2 |
| Uruguai - Clausura | 2021/11/08 12:45 | Atletico Fenix Montevideo v IA Sud America | W | 1-2 |
| Uruguai - Clausura | 2021/11/04 21:45 | IA Sud America v Plaza Colonia | D | 1-1 |
| Uruguai - Clausura | 2021/10/30 19:00 | IA Sud America v Deportivo Maldonado | D | 1-1 |
| Uruguai - Clausura | 2021/10/25 13:15 | Club Atlético Progreso v IA Sud America | D | 0-0 |
| Uruguai - Clausura | 2021/10/21 14:00 | IA Sud America v Cerro Largo FC | D | 0-0 |