[5] Peñarol 2-0 CA River Plate [4] 2021-08-01 21:00
Estádio: Estádio Campeão do Siglo Round: 12
Juiz: Christian Ferreyra Home Manager: Jose Mauricio Larriera Away Manager: Gustavo Diaz Dominguez
Head to Head
| Uruguai - Clausura | 2021/03/06 23:15 | Peñarol v CA River Plate | W | 2-0 |
| Uruguai - Torneo Intermedio | 2020/10/17 21:00 | Peñarol v CA River Plate | L | 1-2 |
| Uruguai - Apertura | 2020/09/09 18:15 | CA River Plate v Peñarol | D | 0-0 |
| Uruguai - Clausura | 2019/11/09 22:00 | Peñarol v CA River Plate | W | 1-0 |
| Uruguai - Torneo Intermedio | 2019/08/24 18:00 | CA River Plate v Peñarol | L | 1-0 |
| Uruguai - Apertura | 2019/05/04 18:00 | CA River Plate v Peñarol | W | 0-2 |
| Uruguai - Clausura | 2018/07/29 18:00 | CA River Plate v Peñarol | W | 0-1 |
| Uruguai - Torneo Intermedio | 2018/05/20 22:00 | Peñarol v CA River Plate | W | 6-0 |
Home History
| Uruguai - Apertura | 2021/07/25 18:00 | Liverpool Montevideo v Peñarol | D | 3-3 |
| Copa Sul-Americana | 2021/07/23 00:30 | Peñarol v Nacional de Football | L | 0-1 |
| Copa Sul-Americana | 2021/07/16 00:30 | Nacional de Football v Peñarol | W | 1-2 |
| Uruguai - Apertura | 2021/07/11 23:30 | Peñarol v Cerrito | W | 2-0 |
| Uruguai - Apertura | 2021/07/04 19:00 | Nacional de Football v Peñarol | L | 2-0 |
| Uruguai - Apertura | 2021/06/26 21:00 | Peñarol v Villa Espanola | D | 1-1 |
| Uruguai - Apertura | 2021/06/23 18:45 | Torque v Peñarol | W | 0-1 |
| Uruguai - Apertura | 2021/06/20 18:45 | Peñarol v Deportivo Maldonado | W | 4-0 |
Away History
| Uruguai - Apertura | 2021/07/17 15:45 | CA River Plate v Rentistas | D | 0-0 |
| Uruguai - Apertura | 2021/07/10 20:15 | Montevideo Wanderers v CA River Plate | W | 1-2 |
| Uruguai - Apertura | 2021/07/03 17:00 | CA River Plate v Boston River | D | 1-1 |
| Uruguai - Apertura | 2021/06/26 18:00 | Atletico Fenix Montevideo v CA River Plate | W | 3-4 |
| Uruguai - Apertura | 2021/06/22 18:00 | CA River Plate v Plaza Colonia | L | 0-1 |
| Uruguai - Apertura | 2021/06/19 13:00 | IA Sud America v CA River Plate | W | 1-2 |
| Uruguai - Apertura | 2021/06/12 18:00 | CA River Plate v Club Atlético Progreso | W | 4-0 |
| Uruguai - Apertura | 2021/06/06 20:15 | Cerro Largo FC v CA River Plate | W | 2-4 |