[2] River Plate Asuncion 2-1 Peñarol [1] 2021-05-18 22:15
Estádio: Estádio Defensores do Chaco Round: 5
Juiz: Fernando Echenique Home Manager: Celso Ayala Away Manager: Jose Mauricio Larriera
Head to Head
| Copa Sul-Americana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | L | 3-0 |
Home History
| Paraguai - División Profesional | 2021/05/16 21:45 | River Plate Asuncion v Cerro Porteño | D | 1-1 |
| Copa Sul-Americana | 2021/05/14 00:30 | River Plate Asuncion v Sport Huancayo | W | 2-1 |
| Paraguai - División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asuncion | D | 0-0 |
| Copa Sul-Americana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | L | 3-0 |
| Paraguai - División Profesional | 2021/05/03 23:00 | River Plate Asuncion v Club Libertad | L | 1-3 |
| Copa Sul-Americana | 2021/04/29 22:15 | Sport Huancayo v River Plate Asuncion | W | 1-2 |
| Paraguai - División Profesional | 2021/04/26 22:15 | Sportivo Luqueño v River Plate Asuncion | D | 2-2 |
| Copa Sul-Americana | 2021/04/23 00:30 | River Plate Asuncion v Corinthians | D | 0-0 |
Away History
| Copa Sul-Americana | 2021/05/14 00:30 | Peñarol v Corinthians | W | 4-0 |
| Copa Sul-Americana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | W | 3-0 |
| Copa Sul-Americana | 2021/04/29 22:15 | Corinthians v Peñarol | W | 0-2 |
| Copa Sul-Americana | 2021/04/23 00:30 | Peñarol v Sport Huancayo | W | 5-1 |
| Copa Sul-Americana | 2021/04/14 00:30 | Peñarol v Cerro Largo FC | W | 4-1 |
| Copa Sul-Americana | 2021/04/07 00:30 | Cerro Largo FC v Peñarol | D | 2-2 |
| Uruguai - Clausura | 2021/03/30 00:15 | Peñarol v Atletico Fenix Montevideo | W | 3-1 |
| Uruguai - Clausura | 2021/03/25 19:00 | Club Atlético Progreso v Peñarol | W | 0-2 |